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Cellosaurus ORL-48 (CVCL_S692)

[Text version]
Cell line name ORL-48
Synonyms ORL-48T; 48T
Accession CVCL_S692
Resource Identification Initiative To cite this cell line use: ORL-48 (RRID:CVCL_S692)
Comments Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Population: Indian; Sikh.
Microsatellite instability: Stable (MSS) (PubMed=17273794).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.
Sequence variations
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Thr3033Asnfs*11 (c.9097dupA); ClinVar=VCV000038208; Zygosity=Unspecified (PubMed=27050151).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu294Serfs*51 (c.876delA) (p.Phe292fs); Zygosity=Unspecified (PubMed=17273794; PubMed=24224046; PubMed=27050151).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu336Ter (c.1006G>T); Zygosity=Unspecified (PubMed=17273794; PubMed=24224046; PubMed=27050151).
Disease Gingival squamous cell carcinoma (NCIt: C129857)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 79Y
Category Cancer cell line
STR profile Source(s): PubMed=25275298; PubMed=27050151

Markers:
AmelogeninX
CSF1PO10 (PubMed=25275298)
10,11 (PubMed=27050151)
D2S133819,25
D3S135815
D5S81811 (PubMed=25275298)
11,12 (PubMed=27050151)
D7S82011
D8S117912,15
D13S31712
D16S53911,13
D18S5114
D19S43313
D21S1129,32.2
FGA24,25
Penta D9,11
Penta E7,18
TH016,9
TPOX11
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=17273794; DOI=10.3892/ijmm.19.3.453
Hamid S., Lim K.P., Zain R.B., Ismail S.M., Lau S.H., Mustafa W.M.W., Abraham M.T., Nam N.A., Teo S.-H., Cheong S.-C.
Establishment and characterization of Asian oral cancer cell lines as in vitro models to study a disease prevalent in Asia.
Int. J. Mol. Med. 19:453-460(2007)

PubMed=24224046; DOI=10.1371/journal.pone.0080229
Zanaruddin S.N.S., Yee P.S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A., Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
PLoS ONE 8:E80229-E80229(2013)

PubMed=25275298; DOI=10.18632/oncotarget.2417
Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z.-Y., Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=27050151; DOI=10.18632/oncotarget.8533
Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.S., Gan C.P., Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G., Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A., Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.
Oncotarget 7:27802-27818(2016)

PubMed=32990596; DOI=10.7554/eLife.57761
Chai A.W.Y., Yee P.S., Price S., Yee S.M., Lee H.M., Tiong V.K.H., Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C., McDermott U., Garnett M.J., Cheong S.-C.
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
eLife 9:e57761.1-e57761.34(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S692
Cell_Model_Passport; SIDM01987
CRISP screens repositories BioGRID_ORCS_Cell_line; 1270
Encyclopedic resources Wikidata; Q54936492
Polymorphism and mutation databases Cosmic; 2296300
Cosmic; 2531640
Cosmic; 2559734
IARC_TP53; 25069
Entry history
Entry creation03-Feb-2014
Last entry update30-Jan-2024
Version number17