ID   ORL-115
AC   CVCL_S690
SY   ORL-115T; 115T
DR   BioGRID_ORCS_Cell_line; 1271
DR   cancercelllines; CVCL_S690
DR   Cell_Model_Passport; SIDM02007
DR   Cosmic; 2531643
DR   Cosmic; 2559735
DR   IARC_TP53; 25070
DR   Wikidata; Q54936490
RX   PubMed=17273794;
RX   PubMed=24224046;
RX   PubMed=27050151;
RX   PubMed=32990596;
CC   Population: Indian.
CC   Microsatellite instability: Stable (MSS) (PubMed=17273794).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>C; ClinVar=VCV000182416; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Leu (c.3140A>T); ClinVar=VCV000013653; Zygosity=Unspecified (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Phe113del (c.339_341delCTT); Zygosity=Unspecified (PubMed=24224046; PubMed=27050151).
CC   Omics: CRISPR phenotypic screen.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.
ST   Source(s): PubMed=27050151
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 8,12
ST   D16S539: 11
ST   D18S51: 14
ST   D19S433: 14
ST   D21S11: 29,30
ST   D2S1338: 18,23
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 8,10
ST   D8S1179: 10,13
ST   FGA: 20,23
ST   TH01: 9
ST   TPOX: 9,10
ST   vWA: 15,16
DI   NCIt; C129857; Gingival squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 16
//
RX   PubMed=17273794; DOI=10.3892/ijmm.19.3.453;
RA   Hamid S., Lim K.P., Zain R.B., Ismail S.M., Lau S.H., Mustafa W.M.W.,
RA   Abraham M.T., Nam N.A., Teo S.-H., Cheong S.-C.;
RT   "Establishment and characterization of Asian oral cancer cell lines as
RT   in vitro models to study a disease prevalent in Asia.";
RL   Int. J. Mol. Med. 19:453-460(2007).
//
RX   PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115;
RA   Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A.,
RA   Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.;
RT   "Common oncogenic mutations are infrequent in oral squamous cell
RT   carcinoma of Asian origin.";
RL   PLoS ONE 8:E80229-E80229(2013).
//
RX   PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689;
RA   Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P.,
RA   Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G.,
RA   Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A.,
RA   Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.;
RT   "Genetically-defined novel oral squamous cell carcinoma cell lines for
RT   the development of molecular therapies.";
RL   Oncotarget 7:27802-27818(2016).
//
RX   PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259;
RA   Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H.,
RA   Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C.,
RA   McDermott U., Garnett M.J., Cheong S.-C.;
RT   "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal
RT   fitness genes in the Hippo pathway.";
RL   eLife 9:e57761.1-e57761.34(2020).
//