ID   Ma-Mel-61e
AC   CVCL_S667
DR   cancercelllines; CVCL_S667
DR   Cosmic; 1846651
DR   Cosmic; 2686449
DR   GEO; GSM2545596
DR   Progenetix; CVCL_S667
DR   Wikidata; Q54903831
RX   PubMed=23348503;
RX   PubMed=28561041;
CC   Sequence variation: Gene deletion; HGNC; HGNC:6190; JAK1; Zygosity=Heterozygous (PubMed=28561041).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_C291 ! Ma-Mel-61a
OI   CVCL_C292 ! Ma-Mel-61b
OI   CVCL_S666 ! Ma-Mel-61c
OI   CVCL_S668 ! Ma-Mel-61f
OI   CVCL_S669 ! Ma-Mel-61g
OI   CVCL_S670 ! Ma-Mel-61h
SX   Male
AG   31Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 10-04-25; Version: 13
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RX   PubMed=28561041; DOI=10.1038/ncomms15440; PMCID=PMC5460020;
RA   Sucker, Antje
RA   Zhao, Fang
RA   Pieper, Natalia
RA   Heeke, Christina
RA   Maltaner, Raffaela
RA   Stadtler, Nadine
RA   Real, Birgit
RA   Bielefeld, Nicola
RA   Howe, Sebastian
RA   Weide, Benjamin
RA   Gutzmer, Ralf
RA   Utikal, Jochen Sven
RA   Loquai, Carmen
RA   Gogas, Helen
RA   Klein-Hitpass, Ludger
RA   Zeschnigk, Michael
RA   Westendorf, Astrid Maria
RA   Trilling, Mirko
RA   Horn, Susanne
RA   Schilling, Bastian
RA   Schadendorf, Dirk
RA   Griewank, Klaus Georg
RA   Paschen, Annette
RT   "Acquired IFNgamma resistance impairs anti-tumor immunity and gives
RT   rise to T-cell-resistant melanoma lesions.";
RL   Nat. Commun. 8:15440.1-15440.15(2017).
//
RX   PubMed=23348503; DOI=10.1126/science.1230062;
RA   Horn, Susanne
RA   Figl, Adina
RA   Rachakonda, P. Sivaramakrishna
RA   Fischer, Christine
RA   Sucker, Antje
RA   Gast, Andreas
RA   Kadel, Stephanie
RA   Moll, Iris
RA   Nagore, Eduardo
RA   Hemminki, Kari
RA   Schadendorf, Dirk
RA   Kumar, Rajiv
RT   "TERT promoter mutations in familial and sporadic melanoma.";
RL   Science 339:959-961(2013).
//