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Cellosaurus K562/ZD1694.C (CVCL_S663)

[Text version]
Cell line name K562/ZD1694.C
Synonyms K562/ZD1694 x C
Accession CVCL_S663
Resource Identification Initiative To cite this cell line use: K562/ZD1694.C (RRID:CVCL_S663)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:5847; ICI D1694 (Tomudex; ZD1694).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=8576277; DOI=10.1007/BF01226268
Takemura Y., Gibson W., Kimbell R., Kobayashi H., Miyachi H., Jackman A.L.
Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug.
J. Cancer Res. Clin. Oncol. 122:109-117(1996)

Cross-references
Encyclopedic resources Wikidata; Q54899419
Entry history
Entry creation03-Feb-2014
Last entry update02-May-2024
Version number18