ID   MOLT-3/TMQ200-MTX500
AC   CVCL_S657
DR   cancercelllines; CVCL_S657
DR   Wikidata; Q54906359
RX   PubMed=7850779;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Selected for resistance to: ChEBI; CHEBI:9737; Trimetrexate.
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_S653 ! MOLT-3/TMQ200
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 16
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RX   PubMed=7850779; DOI=10.1016/0304-3835(94)03616-Q;
RA   Miyachi H., Takemura Y., Kobayashi H., Ando Y.;
RT   "Expression of variant dihydrofolate reductase with decreased binding
RT   affinity to antifolates in MOLT-3 human leukemia cell lines resistant
RT   to trimetrexate.";
RL   Cancer Lett. 88:93-99(1995).
//