ID   MOLT-3/TMQ200-CB371730
AC   CVCL_S654
DR   cancercelllines; CVCL_S654
DR   Wikidata; Q54906358
RX   PubMed=1683871;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:9737; Trimetrexate.
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_S653 ! MOLT-3/TMQ200
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 16
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RX   PubMed=1683871; DOI=10.1007/BF01613282;
RA   Takemura Y., Ohnuma T., Miyachi H., Sekiguchi S.;
RT   "A human leukemia cell line made resistant to two folate analogues,
RT   trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717).";
RL   J. Cancer Res. Clin. Oncol. 117:519-525(1991).
//