ID   RBL30
AC   CVCL_S621
SY   RBL-30
DR   cancercelllines; CVCL_S621
DR   DSMZ; ACC-945
DR   Wikidata; Q54949359
RX   PubMed=2090524;
RX   PubMed=2365495;
RX   PubMed=25326674;
RX   PubMed=30584916;
CC   Doubling time: 6 days (PubMed=2365495); 94 hours (PubMed=25326674); ~5 days (DSMZ=ACC-945).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Arg255Ter (c.763C>T); ClinVar=VCV000126820; Zygosity=Homozygous (PubMed=25326674; PubMed=30584916).
CC   Derived from site: In situ; Eye; UBERON=UBERON_0000970.
ST   Source(s): DSMZ=ACC-945
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 9,13
ST   D18S51: 12,15
ST   D19S433: 14
ST   D21S11: 31.2,32.2
ST   D2S1338: 16,23
ST   D3S1358: 14,19
ST   D5S818: 11,12
ST   D7S820: 10,11
ST   D8S1179: 8,11
ST   FGA: 19,21
ST   Penta D: 9,10
ST   Penta E: 5,10
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 14,17
DI   NCIt; C8714; Unilateral retinoblastoma
DI   ORDO; Orphanet_790; Retinoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   2Y6M
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 14
//
RX   PubMed=2090524; DOI=10.1111/j.1432-0436.1990.tb00479.x;
RA   Griegel S., Heise K., Kindler-Rohrborn A., Rajewsky M.F.;
RT   "In vitro differentiation of human retinoblastoma cells into neuronal
RT   phenotypes.";
RL   Differentiation 45:250-257(1990).
//
RX   PubMed=2365495; DOI=10.1002/ijc.2910460123;
RA   Griegel S., Hong C., Frotschl R., Hulser D.F., Greger V.,
RA   Horsthemke B., Rajewsky M.F.;
RT   "Newly established human retinoblastoma cell lines exhibit an
RT   'immortalized' but not an invasive phenotype in vitro.";
RL   Int. J. Cancer 46:125-132(1990).
//
RX   PubMed=25326674; DOI=10.1007/s00418-014-1285-z;
RA   Busch M.A., Philippeit C., Weise A., Dunker N.;
RT   "Re-characterization of established human retinoblastoma cell lines.";
RL   Histochem. Cell Biol. 143:325-338(2015).
//
RX   PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018;
RA   Schwermer M., Hiber M., Dreesmann S., Rieb A., Theissen J., Herold T.,
RA   Schramm A., Temming P., Steenpass L.;
RT   "Comprehensive characterization of RB1 mutant and MYCN amplified
RT   retinoblastoma cell lines.";
RL   Exp. Cell Res. 375:92-99(2019).
//