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Cellosaurus RBL15 (CVCL_S618)

[Text version]
Cell line name RBL15
Synonyms RBL-15
Accession CVCL_S618
Resource Identification Initiative To cite this cell line use: RBL15 (RRID:CVCL_S618)
Comments Doubling time: 8 days (PubMed=2365495); 45 hours (PubMed=25326674); ~5-7 days (DSMZ=ACC-943).
Derived from site: In situ; Eye; UBERON=UBERON_0000970.
Sequence variations
Disease Bilateral retinoblastoma (NCIt: C8713)
Retinoblastoma (ORDO: Orphanet_790)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 11M
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-943

Markers:
AmelogeninX
CSF1PO11
D2S133819,21
D3S135815,18
D5S81811,13
D7S8208,9
D8S117910,13
D13S31712,13
D16S53911
D18S5112,18
D19S43312,15
D21S1129,30
FGA21,23
Penta D11,13
Penta E12,13
TH016,9.3
TPOX8
vWA16,17

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Publications

PubMed=2090524; DOI=10.1111/j.1432-0436.1990.tb00479.x
Griegel S., Heise K., Kindler-Rohrborn A., Rajewsky M.F.
In vitro differentiation of human retinoblastoma cells into neuronal phenotypes.
Differentiation 45:250-257(1990)

PubMed=2365495; DOI=10.1002/ijc.2910460123
Griegel S., Hong C., Frotschl R., Hulser D.F., Greger V., Horsthemke B., Rajewsky M.F.
Newly established human retinoblastoma cell lines exhibit an 'immortalized' but not an invasive phenotype in vitro.
Int. J. Cancer 46:125-132(1990)

PubMed=7959682; DOI=10.1007/BF00211013
Greger V., Debus N., Lohmann D.R., Hopping W., Passarge E., Horsthemke B.
Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma.
Hum. Genet. 94:491-496(1994)

PubMed=25326674; DOI=10.1007/s00418-014-1285-z
Busch M.A., Philippeit C., Weise A., Dunker N.
Re-characterization of established human retinoblastoma cell lines.
Histochem. Cell Biol. 143:325-338(2015)

PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018
Schwermer M., Hiber M., Dreesmann S., Rieb A., Theissen J., Herold T., Schramm A., Temming P., Steenpass L.
Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines.
Exp. Cell Res. 375:92-99(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-943
Encyclopedic resources Wikidata; Q54949353
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number15