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Cellosaurus NC-37/DC-SIGN (CVCL_S547)

[Text version]
Cell line name NC-37/DC-SIGN
Synonyms NC-37 DC-SIGN+
Accession CVCL_S547
Resource Identification Initiative To cite this cell line use: NC-37/DC-SIGN (RRID:CVCL_S547)
Comments Problematic cell line: Contaminated. Parent cell line (NC-37) has been shown to be a Raji derivative.
Population: African; Nigerian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1641; CD209.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3042 (NC-37)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=14972530; DOI=10.1016/j.virol.2003.09.028
Wu L., Martin T.D., Carrington M.N., KewalRamani V.N.
Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.
Virology 318:17-23(2004)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-9937
Cell line databases/resources cancercelllines; CVCL_S547
Encyclopedic resources Wikidata; Q54907590
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number24