Cellosaurus cell line R06E (CVCL

Cellosaurus R06E (CVCL_S504)

Cross-references
Cell line name	R06E
Synonyms	R-06E; RO6E; AGE1.R06E; AGE1.RO
Accession	CVCL_S504
Resource Identification Initiative	To cite this cell line use: R06E (RRID:CVCL_S504)
Comments	Group: Bat cell line. Group: Patented cell line. Problematic cell line: Partially contaminated. Some cultures of R06E are contaminated with the Vero cell line (PubMed=22754654), this is the case of the culture used in PubMed=20808767. From: ProBioGen AG; Berlin; Germany. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2902. Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257). Doubling time: ~50 hours (PubMed=19540275); ~40 hours (DSMZ=ACC-756). Transformant: NCBI_TaxID; 28285; Adenovirus 5 (Note=E1).
Species of origin	Rousettus aegyptiacus (Egyptian fruit bat) (Pteropus aegyptiacus) (NCBI Taxonomy: 9407)
Originate from same individual	CVCL_Z551 ! R05R
Sex of cell	Sex unspecified
Age at sampling	Fetus
Category	Transformed cell line
Web pages	Info; -; -; https://journals.plos.org/plosntds/article/comment?id=10.1371/annotation/6f6a0bf0-169c-4fd7-93e5-5f75fe8a28b8 Provider; ProBioGen; -; https://www.probiogen.de/virus-production-cell-lines.html
Publications	PubMed=19540275; DOI=10.1016/j.virusres.2009.06.007; PMCID=PMC7172177 Jordan I., Horn D., Oehmke S., Leendertz F.H., Sandig V. Cell lines from the Egyptian fruit bat are permissive for modified vaccinia Ankara. Virus Res. 145:54-62(2009) PubMed=20808767; DOI=10.1371/journal.pntd.0000802; PMCID=PMC2927428 Krahling V., Dolnik O., Kolesnikova L., Schmidt-Chanasit J., Jordan I., Sandig V., Gunther S., Becker S. Establishment of fruit bat cells (Rousettus aegyptiacus) as a model system for the investigation of filoviral infection. PLoS Negl. Trop. Dis. 4:e802.1-e802.9(2010) PubMed=22754654; DOI=10.3390/v4050889; PMCID=PMC3386627 Jordan I., Munster V.J., Sandig V. Authentication of the R06E fruit bat cell line. Viruses 4:889-900(2012) Patent=US8679839 Jordan I., Horn D., Sandig V. Cell line from Rousettus as host cell for pathogen amplification. Patent number US8679839, 25-Mar-2014 PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494 Wurtz N., Penant G., Jardot P., Duclos N., La Scola B. Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile. Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)
Cell line collections (Providers)	BEI_Resources; NR-49168 DSMZ; ACC-756
Cell line databases/resources	DSMZCellDive; ACC-756
Encyclopedic resources	Wikidata; Q54948982
Entry history
Entry creation	03-Feb-2014
Last entry update	10-Apr-2025
Version number	18