ID   NZM017
AC   CVCL_S437
SY   NZM17; NZM 017
DR   cancercelllines; CVCL_S437
DR   Cosmic; 2007655
DR   Cosmic; 2141931
DR   Wikidata; Q54931535
RX   CelloPub=CLPUB00227;
RX   PubMed=23658559;
RX   PubMed=23755070;
RX   PubMed=24455489;
RX   PubMed=32567790;
CC   Doubling time: 43.2 hours (CelloPub=CLPUB00227).
CC   HLA typing: A*68:02,68:02; B*35:01,35:01; C*04:01,04:01 (PubMed=32567790).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=23658559; PubMed=32567790).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=32567790).
CC   Omics: Transcriptome analysis by RNAseq.
ST   Source(s): PubMed=32567790
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 15,16
ST   D19S433: 15,15.2
ST   D21S11: 28.3,29
ST   D2S1338: 20
ST   D3S1358: 15,17
ST   D5S818: 11
ST   D7S820: 11
ST   D8S1179: 10,11
ST   FGA: 20
ST   TH01: 7
ST   TPOX: 9,11
ST   vWA: 17
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 19-12-24; Version: 14
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RX   CelloPub=CLPUB00227;
RA   Daukste L.;
RT   "Mathematical modelling of cancer cell population dynamics.";
RL   Thesis PhD (2012); University of Canterbury; Christchurch; New Zealand.
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RX   PubMed=23658559; DOI=10.3389/fgene.2013.00066; PMCID=PMC3647113;
RA   Stones C.J., Kim J.E., Joseph W.R., Leung E.Y., Marshall E.S.,
RA   Finlay G.J., Shelling A.N., Baguley B.C.;
RT   "Comparison of responses of human melanoma cell lines to MEK and BRAF
RT   inhibitors.";
RL   Front. Genet. 4:66.1-66.6(2013).
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RX   PubMed=23755070; DOI=10.3389/fgene.2013.00097; PMCID=PMC3668138;
RA   Kim J.E., Leung E.Y., Baguley B.C., Finlay G.J.;
RT   "Heterogeneity of expression of epithelial-mesenchymal transition
RT   markers in melanocytes and melanoma cell lines.";
RL   Front. Genet. 4:97.1-97.8(2013).
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RX   PubMed=24455489; DOI=10.3389/fonc.2013.00333; PMCID=PMC3888952;
RA   D'mello S.A.N., Flanagan J.U., Green T.N., Leung E.Y.,
RA   Askarian-Amiri M.E., Joseph W.R., McCrystal M.R., Isaacs R.J.,
RA   Shaw J.H.F., Furneaux C.E., During M.J., Finlay G.J., Baguley B.C.,
RA   Kalev-Zylinska M.L.;
RT   "Evidence that GRIN2A mutations in melanoma correlate with decreased
RT   survival.";
RL   Front. Oncol. 3:333.1-333.9(2014).
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RX   PubMed=32567790; DOI=10.1111/pcmr.12908; PMCID=PMC7818249;
RA   Tran K.B., Gimenez G., Tsai P., Kolekar S., Rodger E.J.,
RA   Chatterjee A., Jabed A., Shih J.-H., Joseph W.R., Marshall E.S.,
RA   Wang Q., Print C.G., Eccles M.R., Baguley B.C., Shepherd P.R.;
RT   "Genomic and signalling pathway characterization of the NZM panel of
RT   melanoma cell lines: a valuable model for studying the impact of
RT   genetic diversity in melanoma.";
RL   Pigment Cell Melanoma Res. 34:136-143(2021).
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