ID   NZM048
AC   CVCL_S423
SY   NZM48
DR   BioSample; SAMN14558343
DR   cancercelllines; CVCL_S423
DR   Cosmic; 2007679
DR   Wikidata; Q54931582
RX   PubMed=23658559;
RX   PubMed=23755070;
RX   PubMed=32567790;
CC   HLA typing: A*03:01,11:01; B*45:01,45:01; C*06:02,07:02 (PubMed=32567790).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=23658559; PubMed=32567790).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=32567790).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
ST   Source(s): PubMed=32567790
ST   Amelogenin: X,Y
ST   CSF1PO: 9,12
ST   D13S317: 8,11
ST   D16S539: 9,11
ST   D18S51: 14,16
ST   D19S433: 15
ST   D21S11: 29,32.2
ST   D2S1338: 17,20
ST   D3S1358: 16,17
ST   D5S818: 12,13
ST   D7S820: 8,10
ST   D8S1179: 14
ST   FGA: 19,20
ST   TH01: 9,9.3
ST   TPOX: 8,11
ST   vWA: 16,18
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_D833 ! NZM042
SX   Male
AG   71Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 14
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RX   PubMed=23658559; DOI=10.3389/fgene.2013.00066;
RA   Stones C.J., Kim J.E., Joseph W.R., Leung E.Y., Marshall E.S.,
RA   Finlay G.J., Shelling A.N., Baguley B.C.;
RT   "Comparison of responses of human melanoma cell lines to MEK and BRAF
RT   inhibitors.";
RL   Front. Genet. 4:66.1-66.6(2013).
//
RX   PubMed=23755070; DOI=10.3389/fgene.2013.00097;
RA   Kim J.E., Leung E.Y., Baguley B.C., Finlay G.J.;
RT   "Heterogeneity of expression of epithelial-mesenchymal transition
RT   markers in melanocytes and melanoma cell lines.";
RL   Front. Genet. 4:97.1-97.8(2013).
//
RX   PubMed=32567790; DOI=10.1111/pcmr.12908;
RA   Tran K.B., Gimenez G., Tsai P., Kolekar S., Rodger E.J.,
RA   Chatterjee A., Jabed A., Shih J.-H., Joseph W.R., Marshall E.S.,
RA   Wang Q., Print C.G., Eccles M.R., Baguley B.C., Shepherd P.R.;
RT   "Genomic and signalling pathway characterization of the NZM panel of
RT   melanoma cell lines: a valuable model for studying the impact of
RT   genetic diversity in melanoma.";
RL   Pigment Cell Melanoma Res. 34:136-143(2021).
//