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Cellosaurus MDA-MB-231 SimpleCell O-GalNAC/O-Man (CVCL_S032)

[Text version]
Cell line name MDA-MB-231 SimpleCell O-GalNAC/O-Man
Accession CVCL_S032
Resource Identification Initiative To cite this cell line use: MDA-MB-231 SimpleCell O-GalNAC/O-Man (RRID:CVCL_S032)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Cell engineered to produce only truncated GalNAc, NeuAc-alpha-2-6-GalNAc and Man O-glycans.
Knockout cell: Method=ZFN; HGNC; HGNC:24338; C1GALT1C1.
Knockout cell: Method=ZFN; HGNC; HGNC:19139; POMGNT1.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S031 (MDA-MB-231 SimpleCell O-GalNAc)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=24101494; DOI=10.1073/pnas.1313446110; PMCID=PMC3876253
Vester-Christensen M.B., Halim A., Joshi H.J., Steentoft C., Bennett E.P., Levery S.B., Vakhrushev S.Y., Clausen H.
Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.
Proc. Natl. Acad. Sci. U.S.A. 110:21018-21023(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S032
Encyclopedic resources Wikidata; Q54904591
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number25