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Cellosaurus HAP1 ANO6 (-) 1 (CVCL_RX74)

[Text version]
Cell line name HAP1 ANO6 (-) 1
Synonyms HZGHC002956c003; ANO6 knockout cell line 20bp deletion in exon 5; KO-T16F
Accession CVCL_RX74
Resource Identification Initiative To cite this cell line use: HAP1 ANO6 (-) 1 (RRID:CVCL_RX74)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; 25240; ANO6.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Children:
CVCL_DX24 (HAP1 ANO6 (-) XKR8 (-) 1)CVCL_DX25 (HAP1 ANO6 (-) XKR8 (-) 2)CVCL_DX26 (HAP1 ANO6 (-) XKR8 (-) 3)
CVCL_DX27 (HAP1 ANO6 (-) XKR8 (-) 4)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=29463790; DOI=10.1038/s41419-018-0373-8
Ousingsawat J., Wanitchakool P., Schreiber R., Kunzelmann K.
Contribution of TMEM16F to pyroptotic cell death.
Cell Death Dis. 9:300.1-300.11(2018)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC002956c003
Cell line databases/resources cancercelllines; CVCL_RX74
Encyclopedic resources Wikidata; Q54872637
Entry history
Entry creation05-Mar-2018
Last entry update30-Jan-2024
Version number11