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Cellosaurus A549-Mx2/EGFP L2A6 (CVCL_RX08)

[Text version]
Cell line name A549-Mx2/EGFP L2A6
Synonyms A549 L2A6; A549L2A6; L2A6
Accession CVCL_RX08
Resource Identification Initiative To cite this cell line use: A549-Mx2/EGFP L2A6 (RRID:CVCL_RX08)
Comments Population: Caucasian.
Biotechnology: Used for a reporter gene assay (RGA) of the human type 1 interferon potency.
Characteristics: Expression of eGFP is under the control of the control of the mouse Mx2 promoter.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=22373148; DOI=10.1186/1753-6561-5-S8-P4; PMCID=PMC3284889
Burgi M., Prieto C., Oggero M., Bollati-Fogolin M., Etcheverrigaray M., Kratje R.
New reporter cell clones to determine the biological activity of human type I interferons.
BMC Proc. 5 Suppl. 8:P4-P4(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RX08
Encyclopedic resources Wikidata; Q54607000
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number12