Cellosaurus cell line NCI-H460-LNM35 (CVCL

Cellosaurus NCI-H460-LNM35 (CVCL_RW33)

Cross-references
Cell line name	NCI-H460-LNM35
Synonyms	LNM35
Accession	CVCL_RW33
Resource Identification Initiative	To cite this cell line use: NCI-H460-LNM35 (RRID:CVCL_RW33)
Comments	Population: Caucasian. Characteristics: Has lymphogenous metastactic properties. Consistently and spontaneously metastasizes to lymph nodes when injected either subcutaneously or orthotopically. Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease	Lung large cell carcinoma (NCIt: C4450)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0459 (NCI-H460)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=10811136 Kozaki K.-i., Miyaishi O., Tsukamoto T., Tatematsu Y., Hida T., Takahashi T., Takahashi T. Establishment and characterization of a human lung cancer cell line NCI-H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation. Cancer Res. 60:2535-2540(2000) PubMed=11464289; DOI=10.1038/sj.onc.1204561 Kozaki K.-i., Koshikawa K., Tatematsu Y., Miyaishi O., Saito H., Hida T., Osada H., Takahashi T. Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis. Oncogene 20:4228-4234(2001)
Cell line databases/resources	cancercelllines; CVCL_RW33
Encyclopedic resources	Wikidata; Q54908059
Entry history
Entry creation	05-Mar-2018
Last entry update	05-Oct-2023
Version number	9