ID   BT012
AC   CVCL_RU28
SY   BT12; BT-12
DR   GEO; GSM2155019
DR   GEO; GSM2155022
DR   Wikidata; Q54798479
RX   PubMed=19544433;
RX   PubMed=20388696;
RX   PubMed=20593219;
RX   PubMed=26095605;
RX   PubMed=27006494;
CC   Group: Cancer stem cell line.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 29-06-23; Version: 6
//
RX   PubMed=19544433; DOI=10.1002/stem.98;
RA   Kelly J.J.P., Stechishin O.D.M., Chojnacki A., Lun X.-Q., Sun B.-C.,
RA   Senger D.L., Forsyth P., Auer R.N., Dunn J.F., Cairncross J.G.,
RA   Parney I.F., Weiss S.;
RT   "Proliferation of human glioblastoma stem cells occurs independently
RT   of exogenous mitogens.";
RL   Stem Cells 27:1722-1733(2009).
//
RX   PubMed=20388696; DOI=10.1093/neuonc/noq031;
RA   Kelly J.J.P., Blough M.D., Stechishin O.D.M., Chan J.A.W.,
RA   Beauchamp D.C., Perizzolo M., Demetrick D.J., Steele L., Auer R.N.,
RA   Hader W.J., Westgate M.R., Parney I.F., Jenkins R.B., Cairncross J.G.,
RA   Weiss S.;
RT   "Oligodendroglioma cell lines containing t(1;19)(q10;p10).";
RL   Neuro-oncol. 12:745-755(2010).
//
RX   PubMed=20593219; DOI=10.1007/s11060-010-0283-9;
RA   Blough M.D., Beauchamp D.C., Westgate M.R., Kelly J.J.P.,
RA   Cairncross J.G.;
RT   "Effect of aberrant p53 function on temozolomide sensitivity of glioma
RT   cell lines and brain tumor initiating cells from glioblastoma.";
RL   J. Neurooncol. 102:1-7(2011).
//
RX   PubMed=26095605; DOI=10.1016/j.stemcr.2015.05.010;
RA   Cusulin C., Chesnelong C., Bose P., Bilenky M., Kopciuk K., Chan J.A.W.,
RA   Cairncross J.G., Jones S.J.M., Marra M.A., Luchman H.A., Weiss S.;
RT   "Precursor states of brain tumor initiating cell lines are predictive
RT   of survival in xenografts and associated with glioblastoma
RT   subtypes.";
RL   Stem Cell Reports 5:1-9(2015).
//
RX   PubMed=27006494; DOI=10.1158/1078-0432.CCR-15-1798;
RA   Lun X.-Q., Wells J.C., Grinshtein N., King J.C., Hao X.-G., Dang N.-H.,
RA   Wang X.-L., Aman A., Uehling D., Datti A., Wrana J.L., Easaw J.C.,
RA   Luchman H.A., Weiss S., Cairncross J.G., Kaplan D.R., Robbins S.M.,
RA   Senger D.L.;
RT   "Disulfiram when combined with copper enhances the therapeutic effects
RT   of temozolomide for the treatment of glioblastoma.";
RL   Clin. Cancer Res. 22:3860-3875(2016).
//