| Cell line name |
PPT2 |
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| Accession |
CVCL_RU11 |
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| Resource Identification Initiative |
To cite this cell line use: PPT2 (RRID:CVCL_RU11) |
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| Comments |
Problematic cell line: Contaminated. Shown to be a HCT 116 derivative (STR profile). Originally thought to originate from a male patient with prostate carcinoma.
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0291 (HCT 116) |
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| Sex of cell |
Male |
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| Age at sampling |
48Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): Millipore=SCC104
Markers:| Amelogenin | X |
| CSF1PO | 7,10 |
| D3S1358 | 12,18,19 |
| D5S818 | 10,11 |
| D7S820 | 11,12 |
| D8S1179 | 12,14 |
| D13S317 | 10,11,13 |
| D16S539 | 11,13,14 |
| D18S51 | 17,18 |
| D21S11 | 29,30 |
| FGA | 18,22,23 |
| Penta D | 9,13 |
| Penta E | 13,14 |
| TH01 | 8,9 |
| TPOX | 8 |
| vWA | 17,18,21,22 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=24086245; DOI=10.1371/journal.pone.0069884; PMCID=PMC3782470
Botchkina G.I., Zuniga E.S., Rowehl R.A., Park R., Bhalla R., Bialkowska A.B., Johnson F., Golub L.M., Zhang Y., Ojima I., Shroyer K.R.
Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24.
PLoS ONE 8:E69884-E69884(2013) |
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| Cross-references |
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| Cell line collections (Providers) |
Millipore; SCC104 - Discontinued
|
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| Cell line databases/resources |
cancercelllines; CVCL_RU11
|
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| Encyclopedic resources |
Wikidata; Q54947804
|
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| Entry history |
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| Entry creation | 05-Mar-2018 |
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| Last entry update | 02-May-2024 |
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| Version number | 10 |
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