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Cellosaurus COLO-679rNutlin20muM (CVCL_RT15)

[Text version]
Cell line name COLO-679rNutlin20muM
Synonyms Colo-679rNutlin20muM
Accession CVCL_RT15
Resource Identification Initiative To cite this cell line use: COLO-679rNutlin20muM (RRID:CVCL_RT15)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_46742; Nutlin-3.
Derived from site: Metastatic; Soft tissue; UBERON=UBERON_0034929.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys238Phe (c.713G>T); ClinVar=VCV000376574; Zygosity=Heterozygous (PubMed=22170099).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1130 (COLO 679)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Web pages Provider; RCCL; -; https://www.wass-michaelislab.org/rccl.php
Publications

PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738
Martin Michaelis, Florian Rothweiler, Susanne Barth, Jaroslaw Cinatl, Marijke van Rikxoort, Nadine Loschmann, Yvonne Voges, Rainer Breitling, Andreas von Deimling, Franz Rodel, Kristoffer Weber ...Show all 17 authors... , Boris Fehse, Elisabeth Mack, Thorsten Stiewe, Hans-Wilhelm Doerr, Daniel Speidel, Jindrich Cinatl Jr.; Show fewer authors
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.
Cell Death Dis. 2:e243.1-e243.8(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RT15
Encyclopedic resources Wikidata; Q54814174
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number13