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Cellosaurus COLO-679rNutlin20muM (CVCL_RT15)

[Text version]
Cell line name COLO-679rNutlin20muM
Synonyms Colo-679rNutlin20muM
Accession CVCL_RT15
Resource Identification Initiative To cite this cell line use: COLO-679rNutlin20muM (RRID:CVCL_RT15)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_46742; Nutlin-3.
Derived from site: Metastatic; Soft tissue; UBERON=UBERON_0034929.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys238Phe (c.713G>T); ClinVar=VCV000376574; Zygosity=Heterozygous (PubMed=22170099).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1130 (COLO 679)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Web pages https://www.wass-michaelislab.org/rccl.php
Publications

PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738
Michaelis M., Rothweiler F., Barth S., Cinatl J., van Rikxoort M., Loschmann N., Voges Y., Breitling R., von Deimling A., Rodel F., Weber K., Fehse B., Mack E., Stiewe T., Doerr H.-W., Speidel D., Cinatl J. Jr.
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.
Cell Death Dis. 2:e243.1-e243.8(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RT15
Encyclopedic resources Wikidata; Q54814174
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number12