Cellosaurus cell line UKF-NB-6rNutlin10muM (CVCL

Cellosaurus UKF-NB-6rNutlin10muM (CVCL_RS15)

Cross-references
Cell line name	UKF-NB-6rNutlin10muM
Accession	CVCL_RS15
Resource Identification Initiative	To cite this cell line use: UKF-NB-6rNutlin10muM (RRID:CVCL_RS15)
Comments	Part of: Resistant Cancer Cell Line (RCCL) collection. Selected for resistance to: ChEBI; CHEBI_46742; Nutlin-3. Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Asn (c.396G>T); ClinVar=VCV000634773; Zygosity=Unspecified (PubMed=22170099). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Unspecified (PubMed=22170099).
Disease	Neuroblastoma (NCIt: C3270) Neuroblastoma (ORDO: Orphanet_635)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_M474 (UKF-NB-6)
Category	Cancer cell line
Web pages	https://www.wass-michaelislab.org/rccl.php
Publications	PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738 Michaelis M., Rothweiler F., Barth S., Cinatl J., van Rikxoort M., Loschmann N., Voges Y., Breitling R., von Deimling A., Rodel F., Weber K., Fehse B., Mack E., Stiewe T., Doerr H.-W., Speidel D., Cinatl J. Jr. Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death Dis. 2:e243.1-e243.8(2011) PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703 Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr. Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs. Transl. Oncol. 6:685-696(2013)
Cell line databases/resources	cancercelllines; CVCL_RS15
Encyclopedic resources	Wikidata; Q54990396
Entry history
Entry creation	05-Mar-2018
Last entry update	19-Dec-2024
Version number	11