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Cellosaurus RVH-421rPLX4720_10muM (CVCL_RR54)

[Text version]
Cell line name RVH-421rPLX4720_10muM
Synonyms RVH-421rPLX4720(10muM)
Accession CVCL_RR54
Resource Identification Initiative To cite this cell line use: RVH-421rPLX4720_10muM (RRID:CVCL_RR54)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln52fs*71 (c.154delC); Zygosity=Heterozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1672 (RVH-421)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Web pages https://www.wass-michaelislab.org/rccl.php
Cell line databases/resources cancercelllines; CVCL_RR54
Encyclopedic resources Wikidata; Q54951479
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number12