ID   IGR-39rPLX4032_20muM
AC   CVCL_RR33
SY   IGR-39rPLX4032(20muM)
DR   cancercelllines; CVCL_RR33
DR   Wikidata; Q54897370
WW   https://www.wass-michaelislab.org/rccl.php
CC   Part of: Resistant Cancer Cell Line (RCCL) collection.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys229Tyrfs*10 (c.686_687delGT); ClinVar=VCV000863486; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2076 ! IGR-39
SX   Male
AG   26Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 05-10-23; Version: 12
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