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Cellosaurus 5637rGEMCI20 (CVCL_RR14)

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Cell line name 5637rGEMCI20
Accession CVCL_RR14
Resource Identification Initiative To cite this cell line use: 5637rGEMCI20 (RRID:CVCL_RR14)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Doubling time: 41.8 hours (PubMed=26055179).
Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:6871; MAPK1; Simple; p.Arg79Lys (c.236G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Tyr325Ter (c.975T>A); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0126 (5637)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
Web pages Provider; RCCL; -; https://www.wass-michaelislab.org/rccl.php
Publications

PubMed=26055179; DOI=10.1016/j.tranon.2015.04.002; PMCID=PMC4487788
Stefan Vallo, Martin Michaelis, Florian Rothweiler, Georg Bartsch, Kilian M. Gust, Dominik M. Limbart, Franz Rodel, Felix Wezel, Axel Haferkamp, Jindrich Cinatl Jr.;
Drug-resistant urothelial cancer cell lines display diverse sensitivity profiles to potential second-line therapeutics.
Transl. Oncol. 8:210-216(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RR14
Encyclopedic resources Wikidata; Q54603871
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number15