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Cellosaurus A549rCDDP2000 (CVCL_RQ47)

[Text version]
Cell line name A549rCDDP2000
Accession CVCL_RQ47
Resource Identification Initiative To cite this cell line use: A549rCDDP2000 (RRID:CVCL_RQ47)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line

PubMed=28746345; DOI=10.1371/journal.pone.0181081
Sarin N., Engel F., Kalayda G.V., Mannewitz M., Cinatl J. Jr., Rothweiler F., Michaelis M., Saafan H., Ritter C.A., Jaehde U., Frotschl R.
Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest.
PLoS ONE 12:E0181081-E0181081(2017)

Cell line databases/resources cancercelllines; CVCL_RQ47
Encyclopedic resources Wikidata; Q54607064
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number9