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Cellosaurus UKBi011-A-4 (CVCL_RM83)

[Text version]
Cell line name UKBi011-A-4
Synonyms APOE-3/4; ApoE 3/4
Accession CVCL_RM83
Resource Identification Initiative To cite this cell line use: UKBi011-A-4 (RRID:CVCL_RM83)
Comments From: Bioneer A/S; Horsholm; Denmark.
Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:613; APOE; Simple; p.Cys130Arg (c.388T>C); ClinVar=VCV000017864; Zygosity=Heterozygous (PubMed=33556820).
  • Mutation; HGNC; HGNC:613; APOE; Simple_corrected; p.Cys130Arg (c.388T>C); ClinVar=VCV000017864; Zygosity=Heterozygous; Note=By CRISPR/Cas9 (PubMed=33556820).
Disease Alzheimer's disease (NCIt: C2866)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_LE34 (UKBi011-A)
Sex of cell Male
Age at sampling 80Y
Category Induced pluripotent stem cell
Publications

PubMed=33556820; DOI=10.1016/j.scr.2021.102180
Schmid B., Holst B., Clausen C., Bahnassawy L., Reinhardt P., Bakker M.H.M., Diaz-Guerra E., Vicario-Abejon C., Martino-Adami P.V., Thoenes M., Ramirez A., Fliessbach K., Grezella C., Brustle O., Peitz M., Ebneth A., Cabrera-Socorro A.
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (E2/E3/E4) and knock-out for the study of APOE biology in health and disease.
Stem Cell Res. 52:102180-102180(2021)

Cross-references
Cell line collections (Providers) EBiSC; UKBi011-A-4 - Discontinued
ECACC; 66540620 - Discontinued
Cell line databases/resources hPSCreg; UKBi011-A-4
Biological sample resources BioSamples; SAMEA104243177
Encyclopedic resources Wikidata; Q54990271
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number8