ID   COLO 357-TRS4
AC   CVCL_RL60
SY   COLO-TRS4
DR   cancercelllines; CVCL_RL60
DR   Wikidata; Q54814100
RX   PubMed=16135802;
CC   Population: African American.
CC   Characteristics: Expresses tetracyclin-inducible SMAD4 siRNA.
CC   Knockout cell: Method=siRNA knockdown; HGNC; 6770; SMAD4.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Derived from site: Metastatic; Celiac axis lymph node; UBERON=UBERON_0002508.
DI   NCIt; C5721; Pancreatic adenosquamous carcinoma
DI   ORDO; Orphanet_424039; Squamous cell carcinoma of pancreas
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0221 ! COLO 357
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-09-24; Version: 11
//
RX   PubMed=16135802; DOI=10.1128/mcb.25.18.8108-8125.2005; PMCID=PMC1234333;
RA   Levy L., Hill C.S.;
RT   "Smad4 dependency defines two classes of transforming growth factor
RT   beta (TGF-beta) target genes and distinguishes TGF-beta-induced
RT   epithelial-mesenchymal transition from its antiproliferative and
RT   migratory responses.";
RL   Mol. Cell. Biol. 25:8108-8125(2005).
//