Cellosaurus cell line PI-1754-MIT (CVCL

Cross-references
Cell line name	PI-1754-MIT
Synonyms	SNCA-Tri-C2; SNCA_Tri-C2
Accession	CVCL_RK98
Resource Identification Initiative	To cite this cell line use: PI-1754-MIT (RRID:CVCL_RK98)
Comments	Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Gene amplification; HGNC; HGNC:11138; SNCA; Triplication; Zygosity=Unspecified (PubMed=26610207).
Disease	Parkinson disease 4, autosomal dominant (NCIt: C198604) Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_RK97 ! PI-1754-C7
Sex of cell	Male
Age at sampling	42Y
Category	Induced pluripotent stem cell
Publications	PubMed=26610207; DOI=10.1038/cddis.2015.318; PMCID=PMC4670926 Oliveira L.M.A., Falomir-Lockhart L.J., Botelho M.G., Lin K.-H., Wales P., Koch J.C., Gerhardt E., Taschenberger H., Outeiro T.F., Lingor P., Schule B., Arndt-Jovin D.J., Jovin T.M. Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells. Cell Death Dis. 6:e1994.1-e1994.13(2015)
Encyclopedic resources	Wikidata; Q54947377
Entry history
Entry creation	05-Mar-2018
Last entry update	19-Dec-2024
Version number	11