Cellosaurus cell line HAP1 KDM1A (-) 1 (CVCL

Cellosaurus HAP1 KDM1A (-) 1 (CVCL_RK67)

Cross-references
Cell line name	HAP1 KDM1A (-) 1
Synonyms	HZGHC000509c010; KDM1A knockout cell line 10bp deletion; HAP1-LSD1-
Accession	CVCL_RK67
Resource Identification Initiative	To cite this cell line use: HAP1 KDM1A (-) 1 (RRID:CVCL_RK67)
Comments	Group: Haploid karyotype cell line. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:29079; KDM1A. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease	Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174) Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_Y019 (HAP1)
Sex of cell	Male
Age at sampling	40Y
Category	Cancer cell line
Publications	PubMed=29205263; DOI=10.1111/bjh.14983 Sonnemann J., Zimmermann M., Marx C., Ebert F., Becker S., Lauterjung M.-L., Beck J.F. LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in cancer cells. Br. J. Haematol. 183:494-497(2018) PubMed=31659326; DOI=10.1038/s41592-019-0614-5 Smits A.H., Ziebell F., Joberty G., Zinn N., Mueller W.F., Clauder-Munster S., Eberhard D., Falth Savitski M., Grandi P., Jakob P., Michon A.-M., Sun H., Tessmer K., Burckstummer T., Bantscheff M., Steinmetz L.M., Drewes G., Huber W. Biological plasticity rescues target activity in CRISPR knock outs. Nat. Methods 16:1087-1093(2019)
Cell line collections (Providers)	Horizon_Discovery; HZGHC000509c010
Encyclopedic resources	Wikidata; Q54875918
Gene expression databases	ArrayExpress; E-MTAB-7061
Proteomic databases	PRIDE; PXD010335
Entry history
Entry creation	05-Mar-2018
Last entry update	19-Dec-2024
Version number	13