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Cellosaurus CLC5 (CVCL_RH15)

[Text version]
Cell line name CLC5
Synonyms Chinese Liver Cancer cell line 5
Accession CVCL_RH15
Resource Identification Initiative To cite this cell line use: CLC5 (RRID:CVCL_RH15)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Population: Chinese.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Genome sequenced.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Glu709Ter (c.2125G>T); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu68Ter (c.202G>T); ClinVar=VCV000224551; Zygosity=Unspecified (PubMed=27273737; PubMed=31378681).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): PubMed=27273737; PubMed=31378681

Markers:
AmelogeninX
CSF1PO9
D5S81811,12
D7S8209,12
D13S3178
D16S5399,13
TH018
TPOX11,12
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=27273737; DOI=10.1038/srep27411; PMCID=PMC4895220
Qiu Z.-X., Zou K.-K., Zhuang L.-P., Qin J.-J., Li H., Li C., Zhang Z.-T., Chen X.-T., Cen J., Meng Z.-Q., Zhang H.-B., Li Y.-X., Hui L.-J.
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers.
Sci. Rep. 6:27411-27411(2016)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RH15
LIMORE; CLC5
Encyclopedic resources Wikidata; Q54813584
Gene expression databases GEO; GSM2070040
Sequence databases EGA; EGAS00001001678
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number12