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Cellosaurus CLC1 (CVCL_RH12)

[Text version]
Cell line name CLC1
Synonyms Chinese Liver Cancer cell line 1
Accession CVCL_RH12
Resource Identification Initiative To cite this cell line use: CLC1 (RRID:CVCL_RH12)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Population: Chinese.
Doubling time: 33.28 hours (PubMed=31378681).
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Genome sequenced.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly34Arg (c.100G>A); ClinVar=VCV000376232; Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val143Met (c.427G>A); ClinVar=VCV000142657; Zygosity=Unspecified (PubMed=31378681).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): PubMed=27273737; PubMed=31378681

Markers:
AmelogeninX,Y
CSF1PO10,13
D5S81811,13
D7S8209,10
D13S31712
D16S53911
TH017,9
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=27273737; DOI=10.1038/srep27411
Qiu Z.-X., Zou K.-K., Zhuang L.-P., Qin J.-J., Li H., Li C., Zhang Z.-T., Chen X.-T., Cen J., Meng Z.-Q., Zhang H.-B., Li Y.-X., Hui L.-J.
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers.
Sci. Rep. 6:27411-27411(2016)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001
Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RH12
LIMORE; CLC1
Encyclopedic resources Wikidata; Q54813577
Gene expression databases GEO; GSM2070032
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number11