ID   MCF-7 shPARG
AC   CVCL_RA89
SY   shPARG MCF7
DR   cancercelllines; CVCL_RA89
DR   Wikidata; Q54904325
RX   PubMed=29166620;
CC   Population: Caucasian.
CC   Knockout cell: Method=shRNA knockdown; HGNC; 8605; PARG.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Poly-ADP-ribosylation by proteomics.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 05-10-23; Version: 10
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RX   PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106; PMCID=PMC5728415;
RA   Zhen Y.-L., Zhang Y.-J., Yu Y.-H.;
RT   "A cell-line-specific atlas of PARP-mediated protein
RT   Asp/Glu-ADP-ribosylation in breast cancer.";
RL   Cell Rep. 21:2326-2337(2017).
//