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Cellosaurus MDA-MB-231-BAG (CVCL_R956)

[Text version]
Cell line name MDA-MB-231-BAG
Synonyms MDA-MB-231 BAG
Accession CVCL_R956
Resource Identification Initiative To cite this cell line use: MDA-MB-231-BAG (RRID:CVCL_R956)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=1384607; DOI=10.1016/0959-8049(92)90245-W
Brunner N., Thompson E.W., Spang-Thomsen M., Rygaard J., Dano K., Zwiebel J.A.
lacZ transduced human breast cancer xenografts as an in vivo model for the study of invasion and metastasis.
Eur. J. Cancer 28A:1989-1995(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_R956
Anatomy/cell type resources BTO; BTO_0004474
Encyclopedic resources Wikidata; Q54904596
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number24