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Cellosaurus J14 (CVCL_R861)

[Text version]
Cell line name J14
Synonyms Jurkat J14; J14-v-29
Accession CVCL_R861
Resource Identification Initiative To cite this cell line use: J14 (RRID:CVCL_R861)
Comments Population: Caucasian.
Characteristics: Deficient in the expression of LCP2 (SLP-76) (PubMed=9665884).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC190

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,17,18
D5S8189
D7S8208,11
D8S117912,13,14,15
D13S3178,14,15
D16S53911
D18S5113,21,22
D21S1131.2,32.2,33.2
FGA20,21
Penta D11,13
Penta E10,12
TH016,9.3
TPOX8,10
vWA18,19,20

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Publications

PubMed=9665884; DOI=10.1126/science.281.5375.413
Yablonski D., Kuhne M.R., Kadlecek T., Weiss A.
Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.
Science 281:413-416(1998)

Cross-references
Cell line collections (Providers) Millipore; SCC190
Cell line databases/resources cancercelllines; CVCL_R861
Encyclopedic resources Wikidata; Q54898441
Experimental variables resources EFO; EFO_0022542
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number20