| Cell line name |
A375-12R8-1 |
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| Synonyms |
12R8-1 |
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| Accession |
CVCL_R749 |
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| Resource Identification Initiative |
To cite this cell line use: A375-12R8-1 (RRID:CVCL_R749) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:75045; Dabrafenib (Tafinlar; GSK2118436).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. |
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| Sequence variations |
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
|
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| Disease |
Amelanotic melanoma (NCIt: C3802) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_R745 (A375PF11) |
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| Sex of cell |
Female |
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| Age at sampling |
54Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=22389471; DOI=10.1158/1535-7163.MCT-11-0989
Greger J.G., Eastman S.D., Zhang V., Bleam M.R., Hughes A.M., Smitheman K.N., Dickerson S.H., Laquerre S.G., Liu L., Gilmer T.M.
Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations.
Mol. Cancer Ther. 11:909-920(2012) Patent=US9402846
Dumble M., Gilmer T.M., Kumar R., Laquerre S.G., Lebowitz P.F., Morris S.R.
Combination of inhibitor of B-Raf and an inhibitor of Akt in the treatment of cancer.
Patent number US9402846, 02-Aug-2016 |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_R749
|
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| Encyclopedic resources |
Wikidata; Q54606759
|
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| Polymorphism and mutation databases |
Cosmic; 1890488
|
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| Entry history |
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| Entry creation | 05-Nov-2013 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 18 |
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