Cell line name |
A375-12R5-1 |
Synonyms |
12R5-1 |
Accession |
CVCL_R746 |
Resource Identification Initiative |
To cite this cell line use: A375-12R5-1 (RRID:CVCL_R746) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:75045; Dabrafenib (Tafinlar; GSK2118436). Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. |
Sequence variations |
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
|
Disease |
Amelanotic melanoma (NCIt: C3802) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_R745 (A375PF11) |
Sex of cell |
Female |
Age at sampling |
54Y |
Category |
Cancer cell line |
Publications | PubMed=22389471; DOI=10.1158/1535-7163.MCT-11-0989 Greger J.G., Eastman S.D., Zhang V., Bleam M.R., Hughes A.M., Smitheman K.N., Dickerson S.H., Laquerre S.G., Liu L., Gilmer T.M. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol. Cancer Ther. 11:909-920(2012) Patent=US9402846 Dumble M., Gilmer T.M., Kumar R., Laquerre S.G., Lebowitz P.F., Morris S.R. Combination of inhibitor of B-Raf and an inhibitor of Akt in the treatment of cancer. Patent number US9402846, 02-Aug-2016 |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_R746
|
Encyclopedic resources |
Wikidata; Q54606754
|
Polymorphism and mutation databases |
Cosmic; 1890494
|
Entry history |
Entry creation | 05-Nov-2013 |
Last entry update | 10-Sep-2024 |
Version number | 18 |
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