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Cellosaurus GM10863 (CVCL_R615)

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Cell line name GM10863
Synonyms GM10863A; CEPH 1375.02; CEPH-137502; 1375-02
Accession CVCL_R615
Resource Identification Initiative To cite this cell line use: GM10863 (RRID:CVCL_R615)
Comments Part of: CEPH/Utah pedigree cell line collection.
Part of: International Genome Sample Resource (1000 genomes project) cell lines.
Part of: International Histocompatibility Workshop cell lines.
Registration: CEPH Families Reference Panel; 137502.
Population: Caucasian; Utah residents with ancestry from Northern and Western Europe.
Virology: Contains a chromosomally integrated human herpesvirus 6B (CI-HHV-6B).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: CNV analysis.
Omics: Genome sequenced.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 2621; CYP2C19; Simple; p.Pro227Pro (c.681G>A); ClinVar=VCV000016897; Zygosity=Unspecified; Note=Cryptic splice acceptor activation. CYP2C19*2 allele (Coriell=GM10863).
HLA typing Source: IPD-IMGT/HLA=10069
Class II
HLA-DPDPB1*04:01,06:01
HLA-DQDQA1*01:01,03:01
DQB1*03:02,05:03
HLA-DRDRB1*04:04,14:04
DRB3*02
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Transformed cell line
Web pages https://www.cephb.fr/en/familles_CEPH.php
Publications

CLPUB00447
Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=15514893; DOI=10.1086/426461; PMCID=PMC1182144
Monks S.A., Leonardson A.S., Zhu H., Cundiff P.E., Pietrusiak P., Edwards S., Phillips J.W., Sachs A.B., Schadt E.E.
Genetic inheritance of gene expression in human cell lines.
Am. J. Hum. Genet. 75:1094-1105(2004)

PubMed=17122850; DOI=10.1038/nature05329; PMCID=PMC2669898
Redon R., Ishikawa S., Fitch K.R., Feuk L., Perry G.H., Andrews T.D., Fiegler H., Shapero M.H., Carson A.R., Chen W.-W., Cho E.K., Dallaire S., Freeman J.L., Gonzalez J.R., Gratacos M., Huang J., Kalaitzopoulos D., Komura D., MacDonald J.R., Marshall C.R., Mei R., Montgomery L., Nishimura K., Okamura K., Shen F., Somerville M.J., Tchinda J., Valsesia A., Woodwark C., Yang F.-T., Zhang J.-J., Zerjal T., Zhang J., Armengol L., Conrad D.F., Estivill X., Tyler-Smith C., Carter N.P., Aburatani H., Lee C., Jones K.W., Scherer S.W., Hurles M.E.
Global variation in copy number in the human genome.
Nature 444:444-454(2006)

PubMed=19043577; DOI=10.1371/journal.pgen.1000287; PMCID=PMC2583954
Choy E., Yelensky R., Bonakdar S., Plenge R.M., Saxena R., De Jager P.L., Shaw S.Y., Wolfish C.S., Slavik J.M., Cotsapas C., Rivas M.A., Dermitzakis E.T., Cahir-McFarland E., Kieff E.D., Hafler D.A., Daly M.J., Altshuler D.M.
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.
PLoS Genet. 4:E1000287-E1000287(2008)

PubMed=20856902; DOI=10.1371/journal.pbio.1000480; PMCID=PMC2939022
Cheung V.G., Nayak R.R., Wang I.X.-R., Elwyn S., Cousins S.M., Morley M., Spielman R.S.
Polymorphic cis- and trans-regulation of human gene expression.
PLoS Biol. 8:e1000480.1-e1000480.14(2010)

PubMed=21397061; DOI=10.1016/j.ajhg.2011.02.004; PMCID=PMC3059424
Campbell C.D., Sampas N., Tsalenko A., Sudmant P.H., Kidd J.M., Malig M., Vu T.H., Vives L., Tsang P., Bruhn L., Eichler E.E.
Population-genetic properties of differentiated human copy-number polymorphisms.
Am. J. Hum. Genet. 88:317-332(2011)

PubMed=24057213; DOI=10.1093/nar/gkt840; PMCID=PMC3874159
Huang Y., Hidalgo-Bravo A., Zhang E.-J., Cotton V.E., Mendez-Bermudez A., Wig G.M., Medina-Calzada Z., Neumann R., Jeffreys A.J., Winney B., Wilson J.F., Clark D.A., Dyer M.J.S., Royle N.J.
Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome.
Nucleic Acids Res. 42:315-327(2014)

Cross-references
Cell line collections (Providers) Coriell; GM10863
Cell line databases/resources CLO; CLO_0024085
IPD-IMGT/HLA; 10069
Biological sample resources BioSample; SAMN00800290
IGSR; NA10863
Encyclopedic resources Wikidata; Q54844703
Gene expression databases GEO; GSM30097
GEO; GSM112509
GEO; GSM112789
GEO; GSM188787
GEO; GSM291620
GEO; GSM291621
GEO; GSM420644
GEO; GSM648916
GEO; GSM862008
GEO; GSM862009
GEO; GSM862010
GEO; GSM862011
GEO; GSM862012
GEO; GSM862013
Entry history
Entry creation05-Nov-2013
Last entry update30-Jan-2024
Version number27