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Cellosaurus RTFK-1 (CVCL_QZ53)

[Text version]
Cell line name RTFK-1
Accession CVCL_QZ53
Resource Identification Initiative To cite this cell line use: RTFK-1 (RRID:CVCL_QZ53)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar).
Misspelling: RTFKK-1; PubMed=22490663; Note=In supplementary figure 2.
Derived from site: In situ; Extrahepatic bile duct; UBERON=UBERON_0003703.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Trp91Ter (c.272G>A); ClinVar=VCV000233650; Zygosity=Homozygous (from parent cell line).
Disease Cholangiocarcinoma (NCIt: C4436)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2214 (TFK-1)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_QZ53
Encyclopedic resources Wikidata; Q54951396
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number11