ID   GIST-T1-R9
AC   CVCL_QW90
SY   GIST-R9; R9
DR   cancercelllines; CVCL_QW90
DR   Cosmic; 2607433
DR   GEO; GSM1701543
DR   Wikidata; Q54835850
RX   PubMed=27997714;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Asp820Tyr (c.2458G>T); ClinVar=VCV000375928; Zygosity=Heterozygous (PubMed=27997714).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Interstitial cell of Cajal; CL=CL_0002088.
DI   NCIt; C3868; Gastrointestinal stromal tumor
DI   ORDO; Orphanet_44890; Gastrointestinal stromal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4976 ! GIST-T1
SX   Female
AG   47Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 30-01-24; Version: 10
//
RX   PubMed=27997714; DOI=10.1002/gcc.22438;
RA   Takahashi T., Elzawahry A., Mimaki S., Furukawa E., Nakatsuka R.,
RA   Nakamura H., Nishigaki T., Serada S., Naka T., Hirota S., Shibata T.,
RA   Tsuchihara K., Nishida T., Kato M.;
RT   "Genomic and transcriptomic analysis of imatinib resistance in
RT   gastrointestinal stromal tumors.";
RL   Genes Chromosomes Cancer 56:303-313(2017).
//