ID   GIST-T1-R8
AC   CVCL_QW86
SY   GIST-R8; R8
DR   cancercelllines; CVCL_QW86
DR   Cosmic; 2607431
DR   GEO; GSM1701541
DR   Wikidata; Q54835849
RX   PubMed=23716303;
RX   PubMed=27997714;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Asp820Tyr (c.2458G>T); ClinVar=VCV000375928; Zygosity=Heterozygous (PubMed=27997714).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Interstitial cell of Cajal; CL=CL_0002088.
DI   NCIt; C3868; Gastrointestinal stromal tumor
DI   ORDO; Orphanet_44890; Gastrointestinal stromal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4976 ! GIST-T1
SX   Female
AG   47Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 30-01-24; Version: 10
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RX   PubMed=23716303; DOI=10.1002/ijc.28282;
RA   Takahashi T., Serada S., Ako M., Fujimoto M., Miyazaki Y.,
RA   Nakatsuka R., Ikezoe T., Yokoyama A., Taguchi T., Shimada K.,
RA   Kurokawa Y., Yamasaki M., Miyata H., Nakajima K., Takiguchi S.,
RA   Mori M., Doki Y., Naka T., Nishida T.;
RT   "New findings of kinase switching in gastrointestinal stromal tumor
RT   under imatinib using phosphoproteomic analysis.";
RL   Int. J. Cancer 133:2737-2743(2013).
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RX   PubMed=27997714; DOI=10.1002/gcc.22438;
RA   Takahashi T., Elzawahry A., Mimaki S., Furukawa E., Nakatsuka R.,
RA   Nakamura H., Nishigaki T., Serada S., Naka T., Hirota S., Shibata T.,
RA   Tsuchihara K., Nishida T., Kato M.;
RT   "Genomic and transcriptomic analysis of imatinib resistance in
RT   gastrointestinal stromal tumors.";
RL   Genes Chromosomes Cancer 56:303-313(2017).
//