ID   B1 [Human leukemia]
AC   CVCL_QW66
SY   B-1
DR   Cosmic; 1037743
DR   Cosmic; 1524791
DR   Cosmic; 2393012
DR   Wikidata; Q54752263
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1423625;
RX   PubMed=1648979;
RX   PubMed=8358709;
RX   PubMed=14671638;
CC   Doubling time: 40-50 hours (PubMed=1648979).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7135; AFF1 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4; Note=In frame (PubMed=1423625; PubMed=8358709).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged
DI   ORDO; Orphanet_585918; B-lymphoblastic leukemia/lymphoma with t(v;11q23.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 19-12-24; Version: 14
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RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=1423625; DOI=10.1016/0092-8674(92)90603-A;
RA   Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G.,
RA   Croce C.M., Canaani E.;
RT   "The t(4;11) chromosome translocation of human acute leukemias fuses
RT   the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.";
RL   Cell 71:701-708(1992).
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RX   PubMed=1648979; DOI=10.1182/blood.V78.1.94.94;
RA   Cohen A., Grunberger T., Vanek W., Dube I.D., Doherty P.J.,
RA   Letarte M., Roifman C.M., Freedman M.H.;
RT   "Constitutive expression and role in growth regulation of
RT   interleukin-1 and multiple cytokine receptors in a biphenotypic
RT   leukemic cell line.";
RL   Blood 78:94-102(1991).
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RX   PubMed=8358709;
RA   Hilden J.M., Chen C.-S., Moore R., Frestedt J., Kersey J.H.;
RT   "Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the
RT   polymerase chain reaction in t(4;11) acute leukemia.";
RL   Cancer Res. 53:3853-3856(1993).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler H.G., Quentmeier H., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//