ID   NCE-G 121
AC   CVCL_N743
SY   NCE-G121; G-121; G121; NeuroChirurgie Eppendorf-Glioma 121
DR   EFO; EFO_0006399
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03471076
DR   EGA; EGAS00001000610
DR   IARC_TP53; 23567
DR   PharmacoDB; G121_381_2019
DR   Wikidata; Q54907655
RX   DOI=10.1007/0-306-46861-1_11;
RX   PubMed=8154317;
RX   PubMed=8253536;
RX   PubMed=8289093;
RX   PubMed=16696057;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
CC   HLA typing: A*01:01,01:01; B*08:01,35:02; C*04:01,07:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=8253536).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Caution: Said to originate from a male patient according to PubMed=8289093 and PubMed=16696057, in contradiction with PubMed=8154317.
CC   Derived from site: In situ; Brain, left occipital-parietal region.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 10
ST   D16S539: 12
ST   D18S51: 15,16
ST   D21S11: 30,32.2
ST   D3S1358: 14,15
ST   D5S818: 12,13
ST   D7S820: 10,12
ST   D8S1179: 11,13
ST   FGA: 20
ST   Penta D: 9,12
ST   Penta E: 11,17
ST   TH01: 6,9
ST   TPOX: 8,10
ST   vWA: 18
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 22
//
RX   DOI=10.1007/0-306-46861-1_11;
RA   Ali-Osman F.;
RT   "Brain tumors.";
RL   (In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=8154317; DOI=10.1007/BF01476489;
RA   Westphal M., Hansel M., Hamel W., Kunzmann R., Holzel F.;
RT   "Karyotype analyses of 20 human glioma cell lines.";
RL   Acta Neurochir. (Wien) 126:17-26(1994).
//
RX   PubMed=8253536; DOI=10.1002/ijc.2910550618;
RA   Anker L., Ohgaki H., Ludeke B.I., Herrmann H.-D., Kleihues P.,
RA   Westphal M.;
RT   "p53 protein accumulation and gene mutations in human glioma cell
RT   lines.";
RL   Int. J. Cancer 55:982-987(1993).
//
RX   PubMed=8289093; DOI=10.1007/BF01324703;
RA   Hamel W., Westphal M., Shepard H.M.;
RT   "Loss in expression of the retinoblastoma gene product in human
RT   gliomas is associated with advanced disease.";
RL   J. Neurooncol. 16:159-165(1993).
//
RX   PubMed=16696057; DOI=10.1136/mp.49.2.M91; PMCID=PMC408028;
RA   Li W.-X., Martinerie C., Zumkeller W., Westphal M., Perbal B.;
RT   "Differential expression of novH and CTGF in human glioma cell
RT   lines.";
RL   Clin. Mol. Pathol. 49:M91-M97(1996).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//