ID   NCE-G 59
AC   CVCL_N729
SY   NCE-G59; G-59; G59; NeuroChirurgie Eppendorf-Glioma 59
DR   EFO; EFO_0006409
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03471229
DR   cancercelllines; CVCL_N729
DR   EGA; EGAS00001000610
DR   IARC_TP53; 2148
DR   PharmacoDB; G59_391_2019
DR   Wikidata; Q54907681
RX   DOI=10.1007/0-306-46861-1_11;
RX   PubMed=8154317;
RX   PubMed=8253536;
RX   PubMed=8289093;
RX   PubMed=16696057;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=36139163;
CC   HLA typing: A*25:01,68:01; B*15:01,44:02; C*03:03,05:01 (PubMed=26589293).
CC   Sequence variation: Gene deletion; HGNC; 8598; PANK1; Zygosity=Homozygous (PubMed=36139163).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=8253536).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Brain, left temporo-medial region.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 10,13
ST   D18S51: 14,16
ST   D21S11: 29,30.2
ST   D3S1358: 14,15
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   D8S1179: 12
ST   FGA: 21,24
ST   Penta D: 10
ST   Penta E: 13
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 14,15
DI   NCIt; C9477; Anaplastic astrocytoma
DI   ORDO; Orphanet_251589; Anaplastic astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 22
//
RX   DOI=10.1007/0-306-46861-1_11;
RA   Ali-Osman F.;
RT   "Brain tumors.";
RL   (In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=8154317; DOI=10.1007/BF01476489;
RA   Westphal M., Hansel M., Hamel W., Kunzmann R., Holzel F.;
RT   "Karyotype analyses of 20 human glioma cell lines.";
RL   Acta Neurochir. (Wien) 126:17-26(1994).
//
RX   PubMed=8253536; DOI=10.1002/ijc.2910550618;
RA   Anker L., Ohgaki H., Ludeke B.I., Herrmann H.-D., Kleihues P.,
RA   Westphal M.;
RT   "p53 protein accumulation and gene mutations in human glioma cell
RT   lines.";
RL   Int. J. Cancer 55:982-987(1993).
//
RX   PubMed=8289093; DOI=10.1007/BF01324703;
RA   Hamel W., Westphal M., Shepard H.M.;
RT   "Loss in expression of the retinoblastoma gene product in human
RT   gliomas is associated with advanced disease.";
RL   J. Neurooncol. 16:159-165(1993).
//
RX   PubMed=16696057; DOI=10.1136/mp.49.2.M91; PMCID=PMC408028;
RA   Li W.-X., Martinerie C., Zumkeller W., Westphal M., Perbal B.;
RT   "Differential expression of novH and CTGF in human glioma cell
RT   lines.";
RL   Clin. Mol. Pathol. 49:M91-M97(1996).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=36139163; DOI=10.3390/biom12091323; PMCID=PMC9496473;
RA   Khadka S., Vien L., Leonard P., Bover L.C., Muller F.;
RT   "Generation and validation of an anti-human PANK3 mouse monoclonal
RT   antibody.";
RL   Biomolecules 12:1323.1-1323.13(2022).
//