| Cell line name |
HCT-116/VM46 |
|---|
| Synonyms |
HCT116/VM46; HCT116-VM46; HCT116(VM46); HCT-VM46; HCT/VM46; VM46 |
|---|
| Accession |
CVCL_N508 |
|---|
| Resource Identification Initiative |
To cite this cell line use: HCT-116/VM46 (RRID:CVCL_N508) |
|---|
| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_75988; Teniposide (VM-26).
Misspelling: HCT166/VM46; Note=Occasionally.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Colon carcinoma (NCIt: C4910) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0291 (HCT 116) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
48Y |
|---|
| Category |
Cancer cell line |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_N508
|
|---|
| Chemistry resources |
ChEMBL-Cells; CHEMBL3307407
ChEMBL-Targets; CHEMBL614575
PubChem_Cell_line; CVCL_N508
|
|---|
| Encyclopedic resources |
Wikidata; Q54882017
|
|---|
| Entry history |
|---|
| Entry creation | 05-Nov-2013 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 20 |
|---|
