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Cellosaurus KMST-6/RAS (CVCL_M810)

[Text version]
Cell line name KMST-6/RAS
Synonyms KMST-6-Ras
Accession CVCL_M810
Resource Identification Initiative To cite this cell line use: KMST-6/RAS (RRID:CVCL_M810)
Comments Population: Japanese.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gln61Leu).
Transformant: NCIt; C129640; Cobalt-60 gamma radiation.
Derived from site: In situ; Whole fetus; UBERON=UBERON_0000323.
Cell type: Fibroblast; CL=CL_0000057.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Pro (c.536A>C); ClinVar=VCV000376611; Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2998 (KMST-6)
Sex of cell Female
Age at sampling 9FW
Category Transformed cell line
Publications

PubMed=3140712
Namba M., Nishitani K., Fukushima F., Kimoto T.
Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenes.
Anticancer Res. 8:947-958(1988)

DOI=10.11418/jtca1981.12.4_313
Namba M., Bai L., Kano Y., Sugihara S., Miyazaki M.
Multistep malignant transformation of human cells: immortalization of human fibroblasts by treatment with 60Co gamma rays and 4-nitroquinoline 1-oxide, and their malignant transformation with the ras oncogene.
Tissue Cult. Res. Commun. 12:313-318(1993)

PubMed=8118610; DOI=10.1007/BF02634342
Jahan I., Mihara K., Bai L., Namba M.
Neoplastic transformation and characterization of human fibroblasts by treatment with 60Co gamma rays and the human c-Ha-ras oncogene.
In Vitro Cell. Dev. Biol. Anim. 29:763-767(1993)

PubMed=8148305
Namba M., Iijima M., Kondo T., Jahan I., Mihara K.
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Hum. Cell 6:253-259(1993)

PubMed=7520808; DOI=10.1007/BF02632040
Kawashima K., Mori M., Furusako S., Usuki H., Shimizu N., Namba M.
Granulocyte-colony stimulating factor (G-CSF) production of human fibroblasts (KMST-6/RAS line) transformed with 60Co gamma rays and c-Ha-ras oncogene.
In Vitro Cell. Dev. Biol. Anim. 30:199-201(1994)

PubMed=7524638
Kawashima K., Mori M., Furusako S., Usuki H., Namba M.
Human fibroblasts (KMST-6/RAS line) transformed with 60Co gamma-rays and c-Ha-ras oncogene constitutively produce a large amount of human granulocyte-colony stimulating factor (G-CSF).
Hum. Cell 7:88-94(1994)

PubMed=8601579; DOI=10.1007/BF01209654
Jahan I., Iijima M., Kondo T., Namba M.
Effects of okadaic acid on cell growth, anchorage-independent growth, and co-cultures of normal (KMS-6), immortalized (KMST-6), and neoplastically transformed (KMST-6T and KMST-6/RAS) human fibroblasts.
J. Cancer Res. Clin. Oncol. 122:249-253(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

Cross-references
Encyclopedic resources Wikidata; Q54900190
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number20