ID   RO-D81-1
AC   CVCL_M779
DR   BioSample; SAMN03151796
DR   Wikidata; Q54950797
RX   PubMed=2538133;
RX   PubMed=23472229;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=23472229). Originally thought to originate from a thyroid gland medullary carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00482.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 21-03-23; Version: 21
//
RX   PubMed=2538133; DOI=10.1001/archotol.1989.01860280076020;
RA   Abemayor E., Sidell N., Juillard G.J.-F.;
RT   "Human medullary thyroid carcinoma. Initial characterization and in
RT   vitro differentiation of two new cell lines.";
RL   Arch. Otolaryngol. Head Neck Surg. 115:478-483(1989).
//
RX   PubMed=23472229; DOI=10.1210/jc.2012-4181;
RA   Dadon T., Ball D., Nelkin B.D.;
RT   "Misidentification of putative medullary thyroid cancer cell lines
RT   RO-H85-1 and RO-D81-1.";
RL   J. Clin. Endocrinol. Metab. 98:954-955(2013).
//