Cellosaurus cell line MOLT-3/Z29 (CVCL

Cellosaurus MOLT-3/Z29 (CVCL_M774)

Cross-references
Cell line name	MOLT-3/Z29
Synonyms	Molt-3/Z29; Molt-3/Z-29; MOLT-3 / Z29
Accession	CVCL_M774
Resource Identification Initiative	To cite this cell line use: MOLT-3/Z29 (RRID:CVCL_M774)
Comments	Population: Caucasian. Virology: Infected by human herpesvirus 6B (HHV-6B) strain Z29. Caution: Was discontinued from BEI_Resources because the cell line seemed to have also been infected by HIV-1 (personal communication of Rashid, Sujatha). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084.
Sequence variations	Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease	Adult T acute lymphoblastic leukemia (NCIt: C9142) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0624 (MOLT-3)
Sex of cell	Male
Age at sampling	19Y
Category	Cancer cell line
Publications	PubMed=1653487; DOI=10.1016/0042-6822(91)90424-A Ablashi D.V., Balachandran N., Josephs S.F., Hung C.-L., Krueger G.R.F., Kramarsky B., Salahuddin S.Z., Gallo R.C. Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 184:545-552(1991)
Cell line collections (Providers)	BEI_Resources; ARP-12185 - Discontinued
Cell line databases/resources	cancercelllines; CVCL_M774
Encyclopedic resources	Wikidata; Q54906362
Entry history
Entry creation	05-Nov-2013
Last entry update	10-Sep-2024
Version number	18