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Cellosaurus SUP-T1/Z29 (CVCL_M772)

[Text version]
Cell line name SUP-T1/Z29
Synonyms SUPT-1 / Z29
Accession CVCL_M772
Resource Identification Initiative To cite this cell line use: SUP-T1/Z29 (RRID:CVCL_M772)
Comments Population: Caucasian.
Virology: Infected by human herpesvirus 6B (HHV-6B) strain Z29 (HHV-6 Foundation).
Caution: Was discontinued from BEI_Resources because the cell line seemed to have also been infected by HIV-1 (personal communication of Rashid, Sujatha).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1714 (SUP-T1)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Web pages Provider; HHV-6 Foundation; -; https://hhv-6foundation.org/reagent/hhv-6b-z29-strain-in-supt-1-cells
Publications

PubMed=11689646; DOI=10.1128/JVI.75.23.11641-11650.2001; PMCID=PMC114751
Michael Mayne, Christopher Cheadle, Samantha S. Soldan, Claudio Cermelli, Yoshihisa Yamano, Nahid Akhyani, Jim E. Nagel, Dennis D. Taub, Kevin G. Becker, Steven Jacobson;
Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: induction of proinflammatory mechanisms.
J. Virol. 75:11641-11650(2001)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-12183 - Discontinued
Cell line databases/resources cancercelllines; CVCL_M772
Encyclopedic resources Wikidata; Q54970884
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number19