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Cellosaurus U1/HIV-1 (CVCL_M769)

[Text version]
Cell line name U1/HIV-1
Synonyms U1
Accession CVCL_M769
Resource Identification Initiative To cite this cell line use: U1/HIV-1 (RRID:CVCL_M769)
Comments Population: Caucasian.
Virology: Latently infected with HIV-1 isolate NY5. The two main sites of integrations are in chromosome 2 and chromosome X (PubMed=28086908).
Doubling time: 36 hours (BEI_Resources=ARP-165).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=3313729; DOI=10.1126/science.3313729
Folks T.M., Justement J.S., Kinter A.L., Dinarello C.A., Fauci A.S.
Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.
Science 238:800-802(1987)

PubMed=2449497; DOI=10.4049/jimmunol.140.4.1117
Folks T.M., Justement J.S., Kinter A.L., Schnittman S., Orenstein J.M., Poli G., Fauci A.S.
Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate.
J. Immunol. 140:1117-1122(1988)

PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276
Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S., Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L., Mallal S., Lewin S.R., Cameron P.U.
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-165
Cell line databases/resources cancercelllines; CVCL_M769
Lonza; 1169
Chemistry resources ChEMBL-Cells; CHEMBL3307351
ChEMBL-Targets; CHEMBL614246
PubChem_Cell_line; CVCL_M769
Encyclopedic resources Wikidata; Q54973623
Entry history
Entry creation05-Nov-2013
Last entry update10-Sep-2024
Version number23