Cell line name |
U1/HIV-1 |
Synonyms |
U1 |
Accession |
CVCL_M769 |
Resource Identification Initiative |
To cite this cell line use: U1/HIV-1 (RRID:CVCL_M769) |
Comments |
Population: Caucasian. Virology: Latently infected with HIV-1 isolate NY5. The two main sites of integrations are in chromosome 2 and chromosome X (PubMed=28086908). Doubling time: 36 hours (BEI_Resources=ARP-165). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0007 (U-937) |
Sex of cell |
Male |
Age at sampling |
37Y |
Category |
Cancer cell line |
Publications | PubMed=3313729; DOI=10.1126/science.3313729 Folks T.M., Justement J.S., Kinter A.L., Dinarello C.A., Fauci A.S. Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science 238:800-802(1987) PubMed=2449497; DOI=10.4049/jimmunol.140.4.1117 Folks T.M., Justement J.S., Kinter A.L., Schnittman S., Orenstein J.M., Poli G., Fauci A.S. Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate. J. Immunol. 140:1117-1122(1988) PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276 Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S., Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L., Mallal S., Lewin S.R., Cameron P.U. HIV integration sites in latently infected cell lines: evidence of ongoing replication. Retrovirology 14:2.1-2.11(2017) |
Cross-references |
Cell line collections (Providers) |
BEI_Resources; ARP-165
|
Cell line databases/resources |
cancercelllines; CVCL_M769
Lonza; 1169
|
Chemistry resources |
ChEMBL-Cells; CHEMBL3307351
ChEMBL-Targets; CHEMBL614246
PubChem_Cell_line; CVCL_M769
|
Encyclopedic resources |
Wikidata; Q54973623
|
Entry history |
Entry creation | 05-Nov-2013 |
Last entry update | 10-Sep-2024 |
Version number | 23 |
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