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Cellosaurus UROtsa/F35 (CVCL_M721)

[Text version]
Cell line name UROtsa/F35
Accession CVCL_M721
Resource Identification Initiative To cite this cell line use: UROtsa/F35 (RRID:CVCL_M721)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=23691160).
Population: Caucasian; Swedish.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Publications

PubMed=16102566; DOI=10.1016/j.taap.2004.12.007; PMCID=PMC2366102
Drobna Z., Waters S.B., Devesa V., Harmon A.W., Thomas D.J., Styblo M.
Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase.
Toxicol. Appl. Pharmacol. 207:147-159(2005)

PubMed=23691160; DOI=10.1371/journal.pone.0064139; PMCID=PMC3656924
Johnen G., Rozynek P., von der Gathen Y., Bryk O., Zdrenka R., Johannes C., Weber D.G., Igwilo-Okuefuna O., Raiko I., Hippler J., Bruning T., Dopp E.
Cross-contamination of a UROtsa stock with T24 cells -- molecular comparison of different cell lines and stocks.
PLoS ONE 8:e64139.1-e64139.13(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M721
Encyclopedic resources Wikidata; Q54991845
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number18