ID   Cheptage
AC   CVCL_M652
SY   Chep-BL; CHEP-BL; CHEP BL; Chep BL; CHEP; Chep
DR   Wikidata; Q54811845
RX   PubMed=2824665;
RX   PubMed=2898508;
RX   PubMed=2943927;
RX   PubMed=2985508;
RX   PubMed=25787276;
RX   PubMed=28960205;
CC   Population: African; Kenyan.
CC   Virology: Contains a complete EBV genome (strain Cheptage) which has been sequenced (PubMed=25787276).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone, jaw, mandible; UBERON=UBERON_0001684.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   10Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 02-05-24; Version: 14
//
RX   PubMed=2824665; DOI=10.1099/0022-1317-68-11-2853;
RA   Young L.S., Yao Q.-Y., Rooney C.M., Sculley T.B., Moss D.J., Rupani H.,
RA   Laux G., Bornkamm G.-W., Rickinson A.B.;
RT   "New type B isolates of Epstein-Barr virus from Burkitt's lymphoma and
RT   from normal individuals in endemic areas.";
RL   J. Gen. Virol. 68:2853-2862(1987).
//
RX   PubMed=2898508; DOI=10.1084/jem.167.6.1811; PMCID=PMC2189677;
RA   Gregory C.D., Murray R.J., Edwards C.F., Rickinson A.B.;
RT   "Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in
RT   Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell
RT   escape from virus-specific T cell surveillance.";
RL   J. Exp. Med. 167:1811-1824(1988).
//
RX   PubMed=2943927; DOI=10.1093/jnci/77.3.681;
RA   Rooney C.M., Gregory C.D., Rowe M., Finerty S., Edwards C.F., Rupani H.,
RA   Rickinson A.B.;
RT   "Endemic Burkitt's lymphoma: phenotypic analysis of tumor biopsy cells
RT   and of derived tumor cell lines.";
RL   J. Natl. Cancer Inst. 77:681-687(1986).
//
RX   PubMed=2985508; DOI=10.1002/ijc.2910350404;
RA   Rowe M., Rooney C.M., Rickinson A.B., Lenoir G.M., Rupani H.,
RA   Moss D.J., Stein H., Epstein M.A.;
RT   "Distinctions between endemic and sporadic forms of Epstein-Barr
RT   virus-positive Burkitt's lymphoma.";
RL   Int. J. Cancer 35:435-441(1985).
//
RX   PubMed=25787276; DOI=10.1128/JVI.03614-14; PMCID=PMC4442510;
RA   Palser A.L., Grayson N.E., White R.E., Corton C., Correia S.,
RA   Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G.,
RA   Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.;
RT   "Genome diversity of Epstein-Barr virus from multiple tumor types and
RT   normal infection.";
RL   J. Virol. 89:5222-5237(2015).
//
RX   PubMed=28960205; DOI=10.1038/cdd.2017.150; PMCID=PMC5762840;
RA   Fitzsimmons L., Boyce A.J., Wei W.-B., Chang C., Croom-Carter D.S.G.,
RA   Tierney R.J., Herold M.J., Bell A.I., Strasser A., Kelly G.L.,
RA   Rowe M.;
RT   "Coordinated repression of BIM and PUMA by Epstein-Barr virus latent
RT   genes maintains the survival of Burkitt lymphoma cells.";
RL   Cell Death Differ. 25:241-254(2018).
//